Bioinformatics used different tools to collect, organize, manage and understand protein information and because of large data and reports created by millions of laboratories, students and resources, bioinformatics scientists used artificial intelligence and machine learning to organize these information in databases.

The Protein database is a collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB. Protein sequences are the fundamental determinants of biological structure and function.

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